Promethazine HCl Oral Alternative ought to be employed with caution in individuals with bone-marrow depression. Leukopenia and agranulocytosis happen to be noted, typically when Promethazine (Promethazine HCl) is Utilized in Affiliation with other known marrow-toxic agents.
It is crucial that Promethazine HCl Oral Answer is measured by having an exact measuring unit (see Safety measures-Information and facts for Patients). A home teaspoon will not be an accurate measuring unit and could lead on to overdosage, specially when 50 % a teaspoon is always to be measured.
Promethazine ought to be applied cautiously in persons with cardiovascular disease or with impairment of liver functionality.
Avoidance and Charge of nausea and vomiting associated with specified types of anesthesia and medical procedures.
The mix of promethazine hydrochloride and codeine phosphate is contraindicated in pediatric clients under six yrs of age. Concomitant administration of promethazine items with other respiratory depressants has an Affiliation with respiratory melancholy, and sometimes death, in pediatric individuals.
Narcotic analgesics may well cause nausea and vomiting by stimulating the chemoreceptor set off zone (CTZ); on the other hand, In addition they depress the vomiting Heart, to make sure that subsequent doses are not likely to website generate vomiting. Nausea is negligible just after standard oral doses of codeine.
Promethazine HCl and Codeine Phosphate Oral Alternative really should be utilised with caution in clients with bone- marrow depression. Leukopenia and agranulocytosis are actually documented, generally when promethazine has been used in Affiliation with other identified marrow-harmful agents.
Extended-time period animal scientific studies haven't been performed to assess the carcinogenic possible of Promethazine, nor are there other animal or human details concerning carcinogenicity, mutagenicity, or impairment of fertility with this drug. Promethazine was nonmutagenic in the Salmonella examination process of Ames.
Promethazine HCl Oral Remedy is contraindicated in comatose states, and in folks recognised to become hypersensitive or to obtain had an idiosyncratic response to Promethazine or to other phenothiazines.
Prevention and control of nausea and vomiting linked to selected different types of anesthesia and surgical procedure.
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Promethazine HCl Oral Option is contraindicated in comatose states, and in people today acknowledged for being hypersensitive or to possess experienced an idiosyncratic reaction to Promethazine or to other phenothiazines.
Observational reports have shown that concomitant use of opioid analgesics and benzodiazepines boosts the chance of drug-linked mortality in comparison to usage of opioids alone.
Physical dependence, the condition in which ongoing administration of your drug is needed to forestall the appearance of a withdrawal syndrome, assumes clinically significant proportions only right after many weeks of ongoing oral opioid use, Though some gentle degree of Bodily dependence may perhaps acquire soon after a few days of opioid therapy.